Case Report : Multiple beta - catenin mutations in hepatocellular lesions arising in Abernethy Malformation
نویسندگان
چکیده
An 18 year old man underwent liver transplantation due to an Abernethy malformation associated with multiple hepatocellular nodules including one which was a rapidly enlarging and was suspicious for malignant transformation. Analysis of the explanted liver showed a spectrum of multiple hepatocellular nodules ranging in appearance from focal nodular hyperplasia, hepatocellular adenoma and to a well differentiated hepatocellular neoplasm borderline for hepatocellular carcinoma. Mutational analysis revealed wildtype beta-catenin expression in the background liver and some nodules, whilst different variants were present in other lesions irrespective of their morphological appearance. No telomerase reverse transcriptase (TERT) promoter mutation was identified. Conclusion: Abernethy malformations can lead to independent genetic events which can result in beta-catenin mutations associated with malignant transformation of hepatocellular nodules. When following up such patients one must therefore have a high index of suspicion, particularly if radiological surveillance reveals a change in the nature of hepatic lesions. AC C EP TE D M AN U SC R IP T ACCEPTED MANUSCRIPT
منابع مشابه
Management strategy after diagnosis of Abernethy malformation: a case report
INTRODUCTION The Abernethy malformation is a rare anomaly with a widely variable clinical presentation. Many diagnostic dilemmas have been reported. Nowadays, with the evolution of medical imaging, diagnosis can be made more easily, but management of patients with an Abernethy malformation is still open for discussion. CASE PRESENTATION In this case study, we describe a 34-year-old Caucasian ...
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